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We seek to elucidate the origin, the evolution
and the heterogeneity of colorectal cancer
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We develop state-of-the-art tools and techniques
to study colorectal cancer heterogeneity and stem cell dynamics
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We are a highly multidisciplinary group, we approach
scientific questions from many different perspectives

Welcome to the Louis Vermeulen laboratory website

Vermeulen Lab seeks to elucidate the origin, the evolution and the heterogeneity of colorectal cancer. We have set up and developed a collection of state-of-the-art tools and techniques to study colorectal cancer heterogeneity and stem cell dynamics. One key characteristic of our group is the highly multidisciplinary composition, which allows us to approach scientific questions from many different perspectives.

Recent news

Inaugural lecture of Prof. Louis Vermeulen

Inaugural lecture of Prof. Louis Vermeulen

On September 6th, 2019, Louis Vermeulen gave his inaugural lecture to officially accept his position as newly appointed professor of Molecular Oncology.
A paper from the Vermeulen Lab on the cover of Nature Protocols

A paper from the Vermeulen Lab on the cover of Nature Protocols

The newest publication of the Vermeulen lab is featured on the cover of Nature Protocols. The paper details methodology for clonal tracing in established colon cancer tissue using marker-independent fluorescent labelling. See: https://www.nature.com/nprot/volumes/14/issues/9 for more details.

Two Dutch Cancer Society (KWF) grants for members of the Vermeulen lab!

In the recent funding round, KWF granted two projects from the Vermeulen Lab. Daniel Miedema was awarded a Young Investigator Grant for his project on tumor growth in colorectal cancer. Nicolas Leveille, together with Louis Vermeulen and Cornelis Murre (UCSD)…

Recent publications

DeepCC: a novel deep learning-based framework for cancer molecular subtype classification.

Oncogenesis, 2019 8(9), 44
Gao F, Wang W, Tan M, Zhu L, Zhang Y, Fessler E, Vermeulen L, Wang X
Molecular subtyping of cancer is a critical step towards more individualized therapy and provides important biological insights into cancer heterogeneity. Although gene expression signature-based classification has been widely demonstrated to be an effective approach in the last decade, the widespread…

Stem cells in homeostasis and cancer of the gut.

Mol. Cancer, 2019 18(1), 66
van der Heijden M, Vermeulen L
The intestinal epithelial lining is one of the most rapidly renewing cell populations in the body. As a result, the gut has been an attractive model to resolve key mechanisms in epithelial homeostasis. In particular the role of intestinal stem…

Prognostic value of low CDX2 expression in colorectal cancers with a high stromal content - a short report.

Cell Oncol (Dordr), 2019
Sandberg TP, Sweere I, van Pelt GW, Putter H, Vermeulen L, Kuppen PJ, Tollenaar RAEM, Mesker WE
Lack of expression of the intestinal transcription factor CDX2 in colorectal cancer (CRC) identifies patients with a poor prognosis. This biomarker has previously been suggested to be prognostic in CRCs with a high stromal content based on mRNA expression data.…