Welcome to the Louis Vermeulen laboratory website
Vermeulen Lab seeks to elucidate the origin, the evolution and the heterogeneity of colorectal cancer. We have set up and developed a collection of state-of-the-art tools and techniques to study colorectal cancer heterogeneity and stem cell dynamics. One key characteristic of our group is the highly multidisciplinary composition, which allows us to approach scientific questions from many different perspectives.
Recent news
Inaugural lecture of Prof. Louis Vermeulen
On September 6th, 2019, Louis Vermeulen gave his inaugural lecture to officially accept his position as newly appointed professor of Molecular Oncology.
A paper from the Vermeulen Lab on the cover of Nature Protocols
The newest publication of the Vermeulen lab is featured on the cover of Nature Protocols. The paper details methodology for clonal tracing in established colon cancer tissue using marker-independent fluorescent labelling. See: https://www.nature.com/nprot/volumes/14/issues/9 for more details.
Two Dutch Cancer Society (KWF) grants for members of the Vermeulen lab!
In the recent funding round, KWF granted two projects from the Vermeulen Lab. Daniel Miedema was awarded a Young Investigator Grant for his project on tumor growth in colorectal cancer. Nicolas Leveille, together with Louis Vermeulen and Cornelis Murre (UCSD)…
Recent publications
DeepCC: a novel deep learning-based framework for cancer molecular subtype classification.
Oncogenesis, 2019 8(9), 44
Gao F, Wang W, Tan M, Zhu L, Zhang Y, Fessler E, Vermeulen L, Wang X
Molecular subtyping of cancer is a critical step towards more individualized therapy and provides important biological insights into cancer heterogeneity. Although gene expression signature-based classification has been widely demonstrated to be an effective approach in the last decade, the widespread…
Stem cells in homeostasis and cancer of the gut.
Mol. Cancer, 2019 18(1), 66
van der Heijden M, Vermeulen L
The intestinal epithelial lining is one of the most rapidly renewing cell populations in the body. As a result, the gut has been an attractive model to resolve key mechanisms in epithelial homeostasis. In particular the role of intestinal stem…
Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts.
Proc. Natl. Acad. Sci. U.S.A., 2019
van der Heijden M, Miedema DM, Waclaw B, Veenstra VL, Lecca MC, Nijman LE, van Dijk E, van Neerven SM, Lodestijn SC, Lenos KJ, de Groot NE, Prasetyanti PR, Arricibita Varea A, Winton DJ, Medema JP, Morrissey E, Ylstra B, Nowak MA, Bijlsma MF, Vermeulen L
Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics of malignant cells within tumors. However, the spatiotemporal dynamics of clonal outgrowth that underlie evolutionary trajectories remain largely unresolved. Here, we sought to unravel the clonal dynamics…