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We seek to elucidate the origin, the evolution
and the heterogeneity of colorectal cancer
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We develop state-of-the-art tools and techniques
to study colorectal cancer heterogeneity and stem cell dynamics
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We are a highly multidisciplinary group, we approach
scientific questions from many different perspectives

Welcome to the Louis Vermeulen laboratory website

Vermeulen Lab seeks to elucidate the origin, the evolution and the heterogeneity of colorectal cancer. We have set up and developed a collection of state-of-the-art tools and techniques to study colorectal cancer heterogeneity and stem cell dynamics. One key characteristic of our group is the highly multidisciplinary composition, which allows us to approach scientific questions from many different perspectives.

Recent news

Two new grants from the Dutch Cancer Society

We received two grant from the Dutch Cancer Society to study: Lithium for the prevention of polypsLouis Vermeulen, together with co-applicants Sanne van Neerven and Evelien Dekker, will investigate whether it is possible to prevent polyp formation in patients with…

Lineage tracing toolkit developed by the Vermeulen Lab featured in Nature

TECHNOLOGY FEATURE: Elusive cancer cells dissected using developmental-biology toolkit Unpicking how cancer stem cells divide and spread could help to explain how tumours grow and evade treatments. See: https://www.nature.com/articles/d41586-021-01029-4

Sanne van Neerven wins the PhD student Award

Sanne van Neerven wins the PhD student Award at the Dutch Society for Stem Cell Research for her talk named ‘Apc-mutant cells act as supercompetitors in intestinal tumour initiation’ See link: https://www.dsscr.nl/nl/annual-meeting/

Recent publications

Predictors of 30-Day Mortality Among Dutch Patients Undergoing Colorectal Cancer Surgery, 2011-2016.

JAMA Netw Open, 2021 4(4), e217737
van den Bosch T, Warps AK, de Nerée Tot Babberich MPM, Stamm C, Geerts BF, Vermeulen L, Wouters MWJM, Dekker JT, Tollenaar RAEM, Tanis PJ, Miedema DM,

Mimicking and surpassing the xenograft model with cancer-on-chip technology.

EBioMedicine, 2021 66103303
Komen J, van Neerven SM, van den Berg A, Vermeulen L, van der Meer AD

AKT3 Expression in Mesenchymal Colorectal Cancer Cells Drives Growth and Is Associated with Epithelial-Mesenchymal Transition.

Cancers (Basel), 2021 13(4),
Buikhuisen JY, Gomez Barila PM, Torang A, Dekker D, de Jong JH, Cameron K, Vitale S, Stassi G, van Hooff SR, Castro MAA, Vermeulen L, Medema JP