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We seek to elucidate the origin, the evolution
and the heterogeneity of colorectal cancer
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We develop state-of-the-art tools and techniques
to study colorectal cancer heterogeneity and stem cell dynamics
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We are a highly multidisciplinary group, we approach
scientific questions from many different perspectives

Welcome to the Louis Vermeulen laboratory website

Vermeulen Lab seeks to elucidate the origin, the evolution and the heterogeneity of colorectal cancer. We have set up and developed a collection of state-of-the-art tools and techniques to study colorectal cancer heterogeneity and stem cell dynamics. One key characteristic of our group is the highly multidisciplinary composition, which allows us to approach scientific questions from many different perspectives.

Recent news

New paper in Cell Stem Cell!

https://pubmed.ncbi.nlm.nih.gov/34358441/

New paper in Cell Reports

https://pubmed.ncbi.nlm.nih.gov/34686335/

Sanne van Neerven wins Birnstiel award for young scientists

https://www.amsterdamumc.org/en/research/institutes/cancer-center-amsterdam/news/sanne-van-neerven-wins-prestigious-international-young-scientists-award.htm

Recent publications

Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas.

Cell Stem Cell, 2021 28(11), 2009-2019.e4
Lodestijn SC, van den Bosch T, Nijman LE, Moreno LF, Schlingemann S, Sheraton VM, van Neerven SM, Koning JJ, Vieira Braga FA, Paauw NJ, Lecca MC, Lenos KJ, Morrissey E, Miedema DM, Winton DJ, Bijlsma MF, Vermeulen L
The tissue dynamics that govern maintenance and regeneration of the pancreas remain largely unknown. In particular, the presence and nature of a cellular hierarchy remains a topic of debate. Previous lineage tracing strategies in the pancreas relied on specific marker…

Marker-free lineage tracing reveals an environment-instructed clonogenic hierarchy in pancreatic cancer.

Cell Rep, 2021 37(3), 109852
Lodestijn SC, Miedema DM, Lenos KJ, Nijman LE, Belt SC, El Makrini K, Lecca MC, Waasdorp C, van den Bosch T, Bijlsma MF, Vermeulen L
Effective treatments for pancreatic ductal adenocarcinoma (PDAC) are lacking, and targeted agents have demonstrated limited efficacy. It has been speculated that a rare population of cancer stem cells (CSCs) drives growth, therapy resistance, and rapid metastatic progression in PDAC. These…

The recurring features of molecular subtypes in distinct gastrointestinal malignancies-A systematic review.

Crit Rev Oncol Hematol, 2021 164103428
Adam RS, Blomberg I, Ten Hoorn S, Bijlsma MF, Vermeulen L
In colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC) and gastric cancer (GC) multiple studies of inter-tumor heterogeneity have identified molecular subtypes, which correlate with clinical features. Our aim was to investigate the attributes of molecular subtypes across three different gastrointestinal…