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We seek to elucidate the origin, the evolution
and the heterogeneity of colorectal cancer
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We develop state-of-the-art tools and techniques
to study colorectal cancer heterogeneity and stem cell dynamics
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We are a highly multidisciplinary group, we approach
scientific questions from many different perspectives

Welcome to the Louis Vermeulen laboratory website

Vermeulen Lab seeks to elucidate the origin, the evolution and the heterogeneity of colorectal cancer. We have set up and developed a collection of state-of-the-art tools and techniques to study colorectal cancer heterogeneity and stem cell dynamics. One key characteristic of our group is the highly multidisciplinary composition, which allows us to approach scientific questions from many different perspectives.

Recent news

The colorecal cancer research platform is now available

The CRC platform (part of the larger BBMRI platform) which connects researchers and clinicians by allowing the sharing of clinical samples to exploit available data to its full potential.  See: BBMRI-NL Catalogue 
Lab outing

Lab outing

We had a great outing this year. On the program we had lama feeding, golfing and BBQing. So much fun to see all colleagues in person again after many months of working at home and video meetings due to covid-19. 

New model to study peritoneal metastases of colorectal origin

The Vermeulen lab and collaborators created a murine model to study peritoneal metastases, a common and poor prognosis disease. The established murine model recapitulates heterogeneity as observed in human peritoneal metastases, which makes it a suitable platform for future (intervention)…

Recent publications

A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity.

Lab Invest, 2020 100(11), 1465-1474
Bastiaenen VP, Klaver CEL, van der Heijden MCS, Nijman LE, Lecca MC, Tanis PJ, Lenos KJ, Vermeulen L
The peritoneum is a common site of dissemination in patients with colorectal cancer. In order to identify high-risk patients and improve therapeutic strategies, a better understanding of the peritoneal dissemination process and the reasons behind the high heterogeneity that is…

DeepCC: a novel deep learning-based framework for cancer molecular subtype classification.

Oncogenesis, 2019 8(9), 44
Gao F, Wang W, Tan M, Zhu L, Zhang Y, Fessler E, Vermeulen L, Wang X
Molecular subtyping of cancer is a critical step towards more individualized therapy and provides important biological insights into cancer heterogeneity. Although gene expression signature-based classification has been widely demonstrated to be an effective approach in the last decade, the widespread…

Stem cells in homeostasis and cancer of the gut.

Mol. Cancer, 2019 18(1), 66
van der Heijden M, Vermeulen L
The intestinal epithelial lining is one of the most rapidly renewing cell populations in the body. As a result, the gut has been an attractive model to resolve key mechanisms in epithelial homeostasis. In particular the role of intestinal stem…