We develop the CloneFit application to compare experimental clone size data with tumor growth models from Lenos et al, NCB 2018, available at: https://github.com/dmmiedema?tab=repositories
a, Experimental data is loaded using the ‘Load experimental’ tab. b, Numerical data panel. In the upper box a clone size distribution is plotted using the parameters that are selected on the slide bars below. c, Inference panel. Using the ‘Parameter inference’ tab, numerical data is compared with the experimental data for all combinations of parameter values. Best fit parameters are shown in the green box and a heat map of the inverse least-square values versus lambda and h is depicted below. Color and size of the dots indicate goodness of fit d, Export distributions panel.